Brain Tumor 2008

Welcome Address
General Information
Registration
Scientific Program
-	Download Program and Abstract Booklet
-	Preliminary Scientific Program
-	List of Poster Presentations
-	List of Oral Presentations
Contact
Disclaimer

This meeting is an activity of

Preliminary Scientific Program

Thursday, December 4, 2008

14.00 - 14.05 Welcome Address: Helmut Kettenmann

14.05 - 15.25 Session I Chair: Frank Heppner

14.05 - 14.45 Roger Abounader (Charlottesville, USA)
The c-Met pathway in brain tumors

14.45 - 15.05 Ilker Eyupoglu (Erlangen, Germany)
Molecular mechanisms of brain tumor induced cell death and edema formation

15.05 - 15.25 Gaetano Finocchiaro (Milano, Italy)
Enhancer of ZESTA 2 is a relevant gene for cancer stem cells and glioma progression

15.25 - 16.00 Poster Session and Coffee Break

16.00 - 17.40 Session II Chair: Matthias Endres

16.00 - 16.40 Katrin Lamszus (Hamburg, Gemany)
Phenotypic diversity of glioma stem cell lines: determinants, assessment and treatment of invasive glioma models

16.40 - 17.20 Maarten van Lohuizen (Amsterdam, Netherlands)
Polycomb repressors controlling stem cell fate: Implications for cancer and development

17.20 - 17.40 Steven Pollard (Cambridge, UK)
Glioma stem cell lines expanded in adherent culture have tumour-specific phenotypes and are suitable for chemical and genetic screens.

17.40 - 18.00 Coffee Break and Poster Session

18.00 - 19.20 Session III Chair: Peter Vajkoczy

18.00 - 18.40 Peter B. Dirks (Toronto, Canada)
Tracking the cancer stem cells in human and mouse brain tumors

18.40 - 19.20 Stefan Momma (Frankfurt/M., Germany)
The reaction of neural stem/progenitor cells to tumors in the adult human brain

19.30 - 20.00 Bus Transfer to Virchow-Ruine

20.00 Reception in the Virchow Ruine / Charité

Friday, December 5, 2008

9.00 - 10.00 Session IV
Chair: Achim Leutz

9.00 - 9.40 Ana Martin-Villalba (Heidelberg, Germany)
Activation of survival signals by the death receptor CD95

9.40 - 10.00 Daniel Bexell (Lund, Sweden)
Multipotent mesenchymal stroma cells act a pericyte-like migratory vehicles in experimental gliomas

10.00 - 10.30 Poster Session and Coffee Break

10.30 - 11.30 Session V
Chair: Jürgen Kiwit

10.30 - 11.10 Rolf Bjerkvig (Bergen, Norway)
Brain tumor stem cells, do they exist?

11.10 - 11.30 Gregor Auf (Talence, France)
IRE1 and glioma angiogenesis

11.30 - 12.30 Lunch

12.30 - 13.10 Session VI
Chair: Rainer Glass

12.30 - 12.50 Rossella Galli (Milano, Italy)
EGFR expression identifies functionally distinct subpopulations of tumor-initiating cells in human glioblastoma multiforme

12.50 - 13.10 Ghazaleh Tabatabai (Tübingen, Germany)
Experimental gliomas attract hematopoietic progenitor cells: a novel approach towards a cellular therapy of malignant gliomas?

13.10 - 13.30 Coffee Break

13.30 - 14.50 Session VII
Chair: Frauke Zipp

13.30 - 14.10 Heidi Philipps (San Francisco, USA)
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma

14.10 - 14.50 Sebastian Brandner (London, UK)
Neural stem cells out of control: The origin of brain tumours?

14.50 Awarding of Poster Prizes

15.00 Departure

List of Poster Presentations

Albrecht, Valerie
Neurosurgical Clinic Grosshadern, Ludwig-Maximilians-University, 81377 München, Germany,
valerie.albrecht@med.uni-muenchen.de
Adult human mesenchymal stem cells and glioma cells form a structural as well as a functional syncytium in vitro
Albrecht, V.; Korte, B.; Buchner, A.; Riesenberg, R.; Mysliwietz, J.; Paron, I.; Tonn, J.-C.; Goldbrunner, R.; Schichor, Ch.

Barciszewska, Anna-Maria
Chair and Clinic of Neurosurgery and Neurotraumatology, Karol Marcinkowski University of Medical Sciences, 60-355 Poznan, Poland,
abarcisz@man.poznan.pl
GENOMIC DNA METHYLATION ANALYSIS IN HUMAN BRAIN GLIOMAS
Barciszewska, A-M; Nowak, S.; Gawronska, I.; Barciszewska, M.

Bernreuther,Christian
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany,
c.bernreuther@uke.uni-hamburg.de
EXPRESSION OF THE EGF-RECEPTOR AND NEURONAL MARKERS IN GLIAL NEOPLASMS: A TISSUE MICROARRAY APPROACH
Bernreuther, C.; Kamradt, T.; Kolevatova, L.; Kellner, A.; Matschke, J.; Simon, R.; Glatzel, M.

Birkenmeier,Gerd
Institute of Biochemistry, University of Leipzig, 04103 Leipzig, Germany,
Gerd.Birkenmeier@medizin.uni-leipzig.de
TUMOR-SUPPRESSIVE ACTIONS OF HUMAN ALPHA-2-MACROGLOBULIN AT ASTROCYTIC TUMOR CELLS
Lindner, I.; Buchold, M.; Bigl, M.; Hutschenreuther, A.; Thal, D.

Castriconi,Roberta
16155 Genova, Italy,
Roberta.Castriconi@unige.it,
NATURAL KILLER CELL MEDIATED RECOGNITION OF HUMAN BRAIN TUMORS
Castriconi, R.; Dondero, A.;Bellora, F.; Daga, A.; Raso, A.; Moretta, L.; Moretta, A.; Bottino, C.

Cheray,Mathilde
Laboratory of Neuroimmunologie, Faculté de Médecine, Université de Limoges, 87025 Limoges; France,
mathilde.cheray@etu.unilim.fr
Sorting and relationship between N- and S-type cells in human neuroblastoma cell line by Sedimentation Field Flow Fractionation (SdFFF). A cellular model for chemotherapy studies.
Cheray, M.; Bégaud-Grimaud, G.; Lazcoz, P.; Castresana, J.S.; Cardot, P.J.P.; Jauberteau, M.O.; Lalloué, F.; Battu, S.

Cholewa,Jadwiga
Developmental Neurobiology, MDC, 13125 Berlin, Germany,
jadwiga.cholewa@mdc-berlin.de
MODULATION OF NEURONAL MEMBRANE PROPERTIES BY THE COXSACKIEVIRUS-ADENOVIRUS RECEPTOR
Cholewa J., Jüttner R. and F. G.Rathjen

Ciechomska,Iwona
Department of Cell Biology, Institute of Experimental Biology, 02-093 Warsaw, Poland,
jcjech@nencki.gov.pl
CONTRIBUTION OF AUTOPHAGY TO DRUG-INDUCED DEATH OF MALIGNANT GLIOMA CELLS
Ciechomska, I.; Kaminska, B.

Clément,Virginie
Centre Romand de Neurochirurgie, Geneva University Hospitals and University of Geneva, 1211 Geneva; Switzerland,
virginie.clement@medecine.unige.ch
Specific morphology and autofluorescence identify self-renewing and tumor-initiating glioma cells
Clement, V.

Colin,Carole
INSERM U911 - CRO2, Université de la Méditerranée - Faculté de Médecine Timone, 13005 Marseille; France,
carole.colin@univmed.fr
PILOCYTIC ASTROCYTOMA OF THE OPTIC PATHWAY: A TUMOR DERIVING FROM RADIAL GLIA CELLS WITH SPECIFIC GENE SIGNATURE
Tchoghandjian, A.; Fernandez, C.; Colin, C.; El Ayachi, I.; Voutsinos-Porche, B.; Fina, F.; Scavarda, D.; Piercecchi-Marti, M.D.; Intagliata, D.; Ouafik, L'H.; Fraslon-Vanhulle, C.; Figarella-Branger, D.

Corno,Daniela
Stem Cell Research Institute, San Raffaele Scientific Institute, 20132 Milan, Italy,
corno.daniela@hsr.it
IDENTIFICATION OF CANCER STEM CELLS IN A MOUSE MODEL OF MEDULLOBLASTOMA AND MOLECULAR COMPARISON WITH NORMAL NEURAL STEM CELLS.
Corno, D.; Cipelletti, B.; Pala, M.; Politi, L.; Bulfone, A.; Galli, R.

Czabanka,Marcus
Dept. of Neurosurgery, Universitätsmedizin Charite, 13353 Berlin; Germany,
marcus.czabanka@charite.de
EFFECTS OF SUNITINIB ON TUMOR HEMODYANAMICS AND DELIVERY OF CHEMOTHERAPY
Czabanka M.; Vinci M.; Heppner F.;Ullrich A.;Vajkoczy P.

Dondero,Alessandra
Department of Experimental Medicine, University of Genova, 16132 Genova, Italy,
alessandra.dondero@unige.it
BOTH CD133 POSITIVE AND CD133 NEGATIVE MEDULLOBLASTOMA CELL LINES EXPRESS LIGANDS FOR TRIGGERING NK RECEPTORS AND ARE SUSCEPTIBLE TO NK-MEDIATED CYTOTOXICITY
Dondero1, A.; Castriconi1, R.; Negri2, F.; Bellora1, F.; Nozza2, P.; Carnemolla3, B.; Raso2, A.; Moretta1,2,4, L.; Moretta1,4 , A.; Bottino1,2, C.

Fuchs,Heiko
Center for Anatomy, Institute for Cell biology and Neurobiology, 10115 Berlin, Germany,
heiko.fuchs@charite.de
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment.
Fuchs H.,Rybak A., Smirnova L., Nitsch R., Wulczyn FG.

Gabrusiewicz,Konrad
Department of Cell Biology, The Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland,
k.gabrusiewicz@nencki.gov.pl
BLOCKING OF MICROGLIAL INFILTRATION AND ACTIVATION IN TRANSPLANTED GLIOMAS WITH SYSTEMICALLY APPLIED CYCLOSPORIN A SIGNIFICANTLY REDUCES TUMOR GROWTH
Gabrusiewicz, K.; Porycka, M.; Frankowska, M.; Kaminska, B.

Gaunitz,Frank
Institut of Biochemistry, University of Leipzig, 04103 Leipzig, Germany,
fgau@medizin.uni-leipzig.de
CARNOSINE INHIBITS GROWTH OF CELLS DERIVED FROM HUMAN GLIOBLASTOMA MULTIFORME AND IN AN ANIMAL MODEL OF HER2/NEU BY INTERFERENCE WITH ANAEROBIC GLYCOLYSIS
Gaunitz, F.; Renner, C.; Seyffarth, A.; Asperger, A.; Zemitzsch, N.; Gebhardt, R.; Meixensberger, J.

Glass,Rainer
Cellular Neurosciences, MDC, 13125 Berlin, Germany,
rainer.glass@mdc-berlin.de
BMP7 release from endogenous neural precursors attenuates tumorigenicity of glioma initiating cells
Chirasani SR1, Sternjak A2, Wend P3, Momma S4, Herold-Mende C5, Besser D3, Synowitz M6 & Kettenmann H1 Glass R1,

Hattermann,Kirsten
Anatomie, Universität Kiel, 24098 Kiel, Germany,
k.hattermann@anat.uni-kiel.de
Expression and function of the chemokine receptor CXCR7 in human gliomas
Hattermann, K.; Held-Feindt, J.; Lucius, R.; Mentlein, R.

Hoene, Victoria
Neonatology, Charité Universitätsmedizin Berlin, CVK, 13353 Berlin, Germany,
victoria.hoene@charite.de
GATA-2 AND -3 ARE HIGHLY EXPRESSED IN NEUROBLASTOMA OF FAVORABLE SUBTYPE
Hoene, V.; Fischer, M.; Ivanova, A.; Berthold, F.; Dame, C.

Holland,Heidrun
University of Leipzig, Translational Centre for Regenerative Medicine, 04103 Leipzig, Germany,
Heidrun.Holland@medizin.uni-leipzig.de
COMPREHESIVE (MOLECULAR) CYTOGENETIC CHARACTERIZATION OF RARE INTRACRANIAL TUMORS
Holland, H.; Krupp, W.; Koschny, R.; Livrea, M.; Schober, R.; Meixensberger, J.; Ahnert, P.

Kahlert,Ulf
Stereotactic Neurosurgery, University Hospital Freiburg, 79106 Freiburg, Germany,
ulf-dietrich.kahlert@uniklinik-freiburg.de
DEFINING IN VITRO CONDITIONS FOR ENRICHMENT OF STEM-LIKE CELL POPULATION IN HUMAN BRAIN TUMOR CULTURES
Kahlert, U.; Maciaczyk, J.; Nikkhah, G.

Kirsch,Matthias
Neurochirurgie, Carl Gustav Carus Universitätsklinikum Dresden, 01307 Dresden, Germany,
matthias.kirsch@uniklinikum-dresden.de
Infrared Spectroscopic Imaging: Towards a Method for Label Free Characterization of Neural Stem Cells
Matthias Kirsch (1), Saskia Küchler (1), Andreas Hermann (2), Edmund Koch (3), Reiner Salzer (4), Gabriele Schackert (1), Gerald Steiner (3)

Kruttwig,Klaus
in-vivo-NMR-Laboratory, Max-Planck-Institute for neurological research, 50931 Köln, Germany,
kruttwig@nf.mpg.de
Development of a 3D in vitro model for longitudinal observation of cell aggregates combining high field magnetic resonance imaging (MRI) with optical techniques
K. Kruttwig; C. Brueggemann; E. Kaijzel; S. Vorhagen; T. Hilger; C. Löwik; M. Hoehn

Lipko,Maciej
Cell Biology, NENCKI Institute of Experimental Biology, 02-093 Warsaw, Poland,
mlipko@nencki.gov.pl
GLOBAL GENE EXPRESSION PROFILING REVEALS DISTINCT GENOMIC RESPONSES IN PRIMARY MICROGLIAL CULTURES
Lipko, M.; Dabrowski, M.; Kaminska, B.

Markovic,Darko
Neurosurgery, Helios Klinikum, 13125 Berlin, Germany,
darko.markovic@helios-kliniken.de
Glioma induce and exploit microglial MT1-MMP expression for tumor expansion
Markovic, DS 1,2; Chirasani, S1; Synowitz, M 1,3; Sliwa, M 4; van Rooijen, N 5; Holmbeck, K6; Kiwit, J 2; Kaminska, B 4; Glass, R 1; Kettenmann, H 1

Parmaksiz,Güliz
Department of Neurosurgery, Charite Universitaetsmedizin, 10115 Berlin, Germany,
gueliz.parmaksiz@charite.de
IN VIVO BIODISTRIBUTION AND MICROVASCULAR BINDING OF A HIGH-AFFINITY MONOCLONAL ANTIBODY FRAGMENT F8-SIP AGAINST THE EXTRA-DOMAIN A OF FIBRONECTIN
Parmaksiz, G.; Czabanka, M.; Neri, D.; Vajkoczy, P.

Porycka,Malgorzata
Department of Cell Biology, The Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland,
m.porycka@nencki.gov.pl
CONTRIBUTION OF PERIPHERAL AND BRAIN MACROPHAGES TO GLIOMA PATHOGENESIS AND THE EFFECT OF SYSTEMIC CYCLOSPORIN A TREATMENT
Porycka, M.; Gabrusiewicz, K.; Kwiatkowska, E.; Kowalczyk, D.; Kaminska, B.

Rybak,Agnieszka
Center for Anatomy, Institute for Cell biology and Neurobiology, 10115 Berlin, Germany,
agnieszkarybak@yahoo.com
Expression and function of the let7 microRNA during mouse CNS development
Rybak, A.; Fuchs, H.; Smirnova, L.; Nitsch R.; Wulczyn G.

Seiz,Marcel
Universitätsmedizin Mannheim, Neurochirurgische Universitätsklinik, 68167 Mannheim, Germany,
marcel.seiz@nch.ma.uni-heidelberg.de
DIFFERENTIATION BETWEEN MALIGNANT TRANSFORMATION AND TUMOUR RECURRENCE BY 68GA-BOMBESIN AND 18F-FDG-PET IN PATIENTS WITH LOW GRADE GLIOMAS
Seiz, M.; Dimitrakopoulou-Strauss A,; Schubert, G.A.; Brockmann, C.; Strauss, L.G.; Eisenhut, M.; Tüttenberg, J.

Tchoghandjian,Aurélie
INSERM U911 - CRO2, Université de la Méditerranée - Faculté de Médecine Timone, 13005 Marseille, France,
aurelie.tchoghandjian@univmed.fr
A2B5 CELLS FROM HUMAN GLIOBLASTOMA HAVE CANCER STEM CELL PROPERTIES
Aurélie Tchoghandjian1*, Nathalie Baeza1*, Carole Colin1, Myriam Cayre2, Philippe Metellus3, Christophe Beclin2, L’Houcine Ouafik1 and Dominique Figarella-Branger1, 4

Tyburczy,Magdalena
Department of Cell Biology, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland,
m.tyburczy@nencki.gov.pl
IDENTIFICATION OF GENES REGULATED BY mTOR IN TUBEROUS SCLEROSIS AND MALIGNANT GLIOMAS
Tyburczy M.E.; Kotulska K.; Jozwiak S.; Pokarowski P.; Mieczkowski J.; Kaminska B.

vom Berg,Johannes
Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, 8057 Zurich, Switzerland,
johannes.vomberg@neuroimm.uzh.ch
DISSECTING CYTOKINE NETWORKS MEDIATING INTRACRANIAL TUMOR CONTROL
vom Berg, J.; Haller, S.; Becher, B.

Watson,Deborah
Neurosurgery, University of Pennsylvania, 19146 Philadelphia, PA, USA,
djw3@mail.med.upenn.edu
BRDU LABELING PATTERN OF THE ROSTRAL MIGRATORY STREAM IN NORMAL CANINE AND FELINE BRAINS
Watson, D.; Malik, S.; Vite, C.; Haskins, M.; Van Winkle, T.

Wisniewski, Pawel
Department of Cell Biology, The Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland,
p.wisniewski@nencki.gov.pl
FAS SIGNALING REGULATES INVASIVENESS OF GLIOMA CELLS AND MMP-2 ACTIVITY VIA NFkB DEPENDENT MODULATION OF TIMP-2 EXPRESSION AND SECRETION
Wisniewski, P.; Ellert-Miklaszewska, A.; Kwiatkowska, A.; Kaminska, B.

List of Oral Presentations

Auf,Gregor
Université Bordeaux 1, INSERM U920, Talence, France,
gregor.auf@charite.de
IRE1 and glioma angiogenesis
Gregor Auf, Sylvaine Guérit, Arnaud Jabouille, Raphaël Pineau, Marion Bouchecareilh, Sophie North, Alexandre Favereaux, Marlène Maitre, Timo Gaiser, Andreas von Deimling, Eric Chevet, Andréas Bikfalvi, Michel Moenner

Bexell,Daniel
Lund Stem Cell Center, BMC B10, , Lund, Sweden,
daniel.bexell@med.lu.se
MULTIPOTENT MESENCHYMAL STROMA CELLS ACT AS PERICYTE-LIKE MIGRATORY VEHICLES IN EXPERIMENTAL GLIOMAS
Bexell, D.; Gunnarsson, S.; Tormin, A.; Darabi, A.; Gisselsson, D.; Roybon, L.; Scheding, S.; Bengzon, J.

Eyupoglu,Ilker
University of Erlangen-Nuremberg, Department of Neurosurgery, Erlangen, Gemany,
ilker.eyupoglu@uk-erlangen.de
Molecular mechanisms of brain tumor induced cell death and edema formation
Ilker Y. Eyüpoglu1, Alexandra Heckel1, Eric Hahnen2, Tobias Engelhorn3, Arnd Doerfler3, Oliver Ganslandt1, Christopher Nimsky1, Michael Buchfelder1 & Nicolai E. Savaskan4

Finocchiaro, Gaetano
Fondazione IRCCS Istituto Neurologico Besta, Milano, Italy,
elisabetta.griggio@istituto-besta.it
ENHANCER OF ZESTE 2 IS A RELEVANT GENE FOR CANCER STEM CELLS AND GLIOMA PROGRESSION
Orzan FN, Pellegatta S, Villa G, Caldera V*, Eoli M, Farinotti M, Marras C, Pollo B, Schiffer D* and Finocchiaro G

Galli,Rossella
San Raffaele Scientific Institute, Stem Cell Research Institute, Milano, Italy,
galli.rossella@hsr.it
EGFR EXPRESSION IDENTIFIES FUNCTIONALLY DISTINCT SUBPOPULATIONS OF TUMOR-INITIATING CELLS - IN HUMAN GLIOBLASTOMA MULTIFORME
Galli, R.; Mazzoleni, S.; Politi, L.; Poliani, P.L.; De Palma, M.

Pollard,Steven
University of Cambridge, Wellcome Trust Centre for Stem Cell Research, Cambridge, UK,
smp54@cam.ac.uk
Glioma stem cell lines expanded in adherent culture have tumour-specific phenotypes and are suitable for chemical and genetic screens.
Pollard, S.; Yoshikawa K.; Smith, A.; Dirks, P.

Tabatabai,Ghazaleh
University of Tübingen, Department of General Neurology, Tübingen, Germany,
ghazaleh.tabatabai@uni-tuebingen.de
EXPERIMENTAL GLIOMAS ATTRACT HEMATOPOIETIC PROGENITOR CELLS: A NOVEL APPROACH TOWARDS A CELLULAR THERAPY OF MALIGNANT GLIOMAS?
Tabatabai, G; Herrmann, C; Möhle, R; Weller; Wick, W

December 4 - 5, 2008

Scientific Program

Download Program and Abstract Booklet

Preliminary Scientific Program

List of Poster Presentations

List of Oral Presentations